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Porous Paclitaxel Mesh Reduces Local Recurrence in Patient-Derived Xenograft Resection Model by Lillian L. Tsai; Danielle M. Fitzgerald; Rong Liu; Jenny T. Korunes-Miller; Eliza Neal; Yin P. Hung; Samantha Bilton; Aaron Hata; Mark W. Grinstaff; Yolonda L. Colson is a Medicine article available to read on EtoBox.

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## Background: Drug-loaded meshes offer a promising delivery strategy for the prevention of local recurrence. patient-derived xenograft (pdx) models are representative of individual patient tumors and predictive of clinical outcomes. ## Methods: A pdx model was established in nsg (nod-scid il2rgamma) mice using tumor tissue from a patient with aggressive lung adenocarcinoma. polyglycolic acid (pga) meshes loaded with paclitaxel (pga+ptx) were electrospun. tumor-bearing mice were randomized into 4 groups after macroscopic complete resection: (1) no treatment (n = 10); (2) intraperitoneal ptx at 20 mg/kg (n = 10); (3) pga mesh without drug (n = 14); and (4) pga+ptx mesh at 12 mg/kg (n = 14). a 1-cm mesh was placed onto the tumor resection beds. groups were observed for local recurrence for 120 postoperative days. ## Results: Pdx mice treated with pga+ptx meshes after resection exhibited a >5-fold increase in recurrence-free survival (p < .0001) compared with systemically treated and untreated control groups. median recurrence-free survival was 24 days for untreated and intraperitoneal ptx groups, 28 days for unloaded pga mesh group, and undefined for the pga+ptx mesh group. ## Conclu

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Author

Lillian L. Tsai; Danielle M. Fitzgerald; Rong Liu; Jenny T. Korunes-Miller; Eliza Neal; Yin P. Hung; Samantha Bilton; Aaron Hata; Mark W. Grinstaff; Yolonda L. Colson

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)