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Can I read Altered Distribution and Synthesis of Laminin-5 (Kalinin) in Oral Lichen Planus, Epithelial Dysplasias and Squamous Cell Carcinomas on EtoBox?
Altered Distribution and Synthesis of Laminin-5 (Kalinin) in Oral Lichen Planus, Epithelial Dysplasias and Squamous Cell Carcinomas by T. KAINULAINEN; H. AUTIO-HARMAINEN; A. OIKARINEN; S. SALO; K. TRYGGVASON; T. SALO is a Medicine article available to read on EtoBox.
What is Altered Distribution and Synthesis of Laminin-5 (Kalinin) in Oral Lichen Planus, Epithelial Dysplasias and Squamous Cell Carcinomas about?
Laminin-5 is a glycoprotein which mediates epithelial cell adhesion to the basement membrane. This study describes the distribution and synthesis of laminin-5 in oral lichen planus, epithelial dysplasias, squamous cell carcinomas and a lymph node metastasis using immunohistochemistry and in situ hybridization. In normal oral mucosa and lichen planus, immunoreaction to the laminin-5 was seen as a thin continuous, delicate line in the basement membrane region, although slight irregularities in the thickness and intensity of the immunoreaction could be detected in some cases with lichen planus. In epithelial dysplasias, the laminin-5 staining was discontinuous and more diffuse compared to lichen planus and normal mucosa. The immunoreaction was generally extracellular, although in some cases with lichen planus and epithelial dysplasia there were a few basal epithelial cells showing cytoplasmic staining. The invasive carcinomas and the lymph node metastasis showed a striking, intense cytoplasmic, staining of the carcinoma cells along the invasive border of the neoplastic islands and in individual infiltrating carcinoma cells. Using in situ hybridization, the laminin-5 gamma 2 chain mRNA
Who reads Altered Distribution and Synthesis of Laminin-5 (Kalinin) in Oral Lichen Planus, Epithelial Dysplasias and Squamous Cell Carcinomas?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- T. KAINULAINEN; H. AUTIO-HARMAINEN; A. OIKARINEN; S. SALO; K. TRYGGVASON; T. SALO
- Publisher
- Oxford University Press (OUP)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)