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Gastric cancer: Laboratory bench to clinic by Jeanmarie Houghton; James G Fox; Timothy C Wang is a Medicine article available to read on EtoBox.

What is Gastric cancer: Laboratory bench to clinic about?

**__Abstract__** Gastric cancer is the second most common cause of cancer‐related mortality worldwide and the 14th overall cause of death. Detection of disease usually occurs at an advanced stage and overall survival rates for gastric cancer are poor. Our current model for gastric cancer progression clearly maintains __Helicobacter__ infection as the primary inducer of gastric metaplastic and neoplastic disease. __Helicobacter pylori__ is a ubiquitous organism, infecting more than half the world’s population. It has been suggested that this infection directly contributes to the formation of gastric cancer in up to 80% of cases; however, gastric malignancy develops in only a subset (< 1%) of infected patients. Therefore, predisposition to __Helicobacter‐__associated gastric cancer is most likely multifactorial, including the interaction of bacterial, host and environmental components. Our understanding of how the organism interacts with the gastric mucosa and synergizes with dietary and other environmental factors to induce malignant mucosal changes is evolving. Indeed, __H. pylori__ has direct effects on the gastric mucosa, but the major factor in disease progression appears to be

Who reads Gastric cancer: Laboratory bench to clinic?

Author

Jeanmarie Houghton; James G Fox; Timothy C Wang

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0815-9319)

Published

2002

Language

EN

Field

Medicine (Health Sciences)