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Erythropoietin-induced Reduction of Hypoxia Before and During Fractionated Irradiation Contributes to Improvement of Radioresponse in Human Glioma Xenografts by Sophie Pinel; Muriel Barberi-Heyob; Elizabeth Cohen-Jonathan; Jean-Louis Merlin; Caroline Delmas; François Plenat; Pascal Chastagner is a Medicine article available to read on EtoBox.
What is Erythropoietin-induced Reduction of Hypoxia Before and During Fractionated Irradiation Contributes to Improvement of Radioresponse in Human Glioma Xenografts about?
Purpose: Our study investigated the influence of recombinant human erythropoietin (rHuEPO) treatment, inducing raised hemoglobin levels in nonanemic mice, on intratumor oxygenation before and during fractionated irradiation. Furthermore, the consequences of rHuEPO administration on tumor response to fractionated radiotherapy (RT) were evaluated. Methods and Materials: Experiments were performed on two human malignant glioma (GBM Nan1 and U87) xenografted in nude mice. RHuEPO was daily delivered (0.3 IU/g/day, 5 days/week). Tumor hypoxia was assessed before (T1) and during (T6) fractionated irradiation using (1) pO 2 -Histograph (Eppendorf, Hamburg, Germany) and (2) the EF5-binding assay. Vascular density was determined using type IV collagen immunostaining. To assess RT efficacy, the irradiation schedule was 20 fractions of 2 Gy, once daily, 5 days/week over 4 weeks. Results: At T1, hemoglobin levels in rHuEPO-treated mice were significantly increased. Percentage of pO 2 values <2.5 mm Hg was reduced in rHuEPO-treated tumors as compared with control groups (37.1 ؎ 19.1% vs. 58.5 ؎ 27.0%; p ؍ 0.009 for GBM Nan1; 81.6 ؎ 13.4% vs. 91.5 ؎ 8.3%; p ؍ 0.035 for U87). The decrease of v
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- Author
- Sophie Pinel; Muriel Barberi-Heyob; Elizabeth Cohen-Jonathan; Jean-Louis Merlin; Caroline Delmas; François Plenat; Pascal Chastagner
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)