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Profile of cognitive deficits in schizophrenia and factor structure of the Czech MATRICS Consensus Cognitive Battery by Bezdicek, Ondrej; Michalec, JiÅí; KaliÅ¡ová, Lucie; Kufa, TomáÅ¡; DÄchtÄrenko, Filip; Chlebovcová, Miriama; Havlík, Filip; Green, Michael F.; Nuechterlein, Keith H. is a Medicine article available to read on EtoBox.

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We aimed to validate the Czech version of the MATRICS Consensus Cognitive Battery (MCCB). The MCCB is a test battery designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. The valid, reliable and replicable measurement of cognition in schizophrenia is of substantial importance for such clinical trial studies. We performed a psychometric analysis of the MCCB composite and domain scores based on ROC analysis of 67 schizophrenia patients and 67 age- and education-matched healthy controls from a total sample of 220 controls. Also, we correlated MCCB variables with scales measuring psychosocial functioning (Personal and Social Performance scale; PSP). The internal consistency of all 10 tests in the MCCB battery was good (Cronbach's α = 0.85 (95% CI [0.83, 0.88])). The discriminative validity for the detection of neurocognitive dysfunction in schizophrenia based on the area under the curve of MCCB composite T-score was ≥90% (95% CI [0.85, 0.96]) and all MCCB domains showed ps < .001. The MCCB global composite and the Speed of Processing domain score significantly predicted the PSP ratings. A confirmatory factor analysis on the whole control samp

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Author

Bezdicek, Ondrej; Michalec, JiÅí; KaliÅ¡ová, Lucie; Kufa, TomáÅ¡; DÄchtÄrenko, Filip; Chlebovcová, Miriama; Havlík, Filip; Green, Michael F.; Nuechterlein, Keith H.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-9964)

Published

2020

Language

EN

Field

Medicine (Health Sciences)