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This document discusses the evaluation and differentiation of macrocytic anemias. It begins by defining macrocytic anemia as a mean cell volume of 100 fL or greater in adults. There are two main categories of macrocytic anemia - megaloblastic and non-megaloblastic. Megaloblastic anemias are caused by deficiencies in vitamin B12 or folic acid and are characterized by morphological changes in red blood cells and neutrophils on peripheral smears, as well as specific biochemical abnormalities. Critical to diagn

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