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Effectiveness of Theophylline Administration in Neonates with Perinatal Asphyxia: a Meta-analysis by Ioannis Bellos; Aakash Pandita; Monika Yachha is a Medicine article available to read on EtoBox.

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## Aim: To evaluate the effects of prophylactic theophylline in renal function and survival rates of asphyxiated newborns. ## Methods: Medline, scopus, cochrane central register of controlled trials, clinicaltrials.gov and google scholar databases were systematically searched. all randomized controlled trials evaluating the efficacy of theophylline in the prevention of perinatal asphyxia were selected. ## Results: A total of seven studies were included with a total of 458 asphyxiated neonates. incidence of acute kidney injury was significantly lower in neonates receiving theophylline (or: 0.24, 95% ci: [0.16, 0.36]), while mortality rates were similar between the two groups (or: 0.86, 95% ci: [0.46, 1.62]). theophylline administration was associated with significantly decreased serum creatinine levels (md: -0.57 mg/dl, 95% ci: [-0.68, -0.46]) and elevated glomerular filtration rate (md: 13.79 ml/min/1.73 m, 95% ci: [11.91, 15.68]) in the third day of life. theophylline also lead to lower β2-microglobulin levels, higher urine output and negative fluid balance. ## Conclusions: The present findings suggest the effectiveness of theophylline in ameliorating renal function of asphyxiated

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Author

Ioannis Bellos; Aakash Pandita; Monika Yachha

Published

2019

Language

EN

Field

Medicine (Health Sciences)