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Transmitter diversity in ganglion cells of the guinea pig gallbladder: An immunohistochemical study by Erin K. Talmage; Wendy A. Pouliot; Ellen B. Cornbrooks; Gary M. Mawe is a Neuroscience article available to read on EtoBox.

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Several neurotransmitters have been reported to exist in the ganglionated plexus of the guinea pig gallbladder. These include substance P, neuropeptide Y (NPY), calcitonin generelated peptide, vasoactive intestinal peptide (VIP), acetylcholine, norepinephrine, serotonin, and dopamine. To determine which neuropeptides are intrinsic to gallbladder ganglia, we performed immunohistochemistry on colchicine-treated preparations. In separate, singlelabeled preparations, a majority of neurons contained substance P-, NPY-, or somatostatin-like immunoreactivity. In double-labeled preparations, a large majority of the neurons that contained substance P-like immunoreactivity also contained NPY-like immunoreactivity and somatostatin-like immunoreactivity. Immunoreactivity for VIP was present in a small percentage of the gallbladder neurons which did not contain substance P-like immunoreactivity. Additional experiments were done to test for the presence of other compounds, known to exist in the neurons of the gut. Although immunoreactivity was found in control preparations of small intestine, the ganglionated plexus of the gallbladder lacked immunoreactivity for galanin, dynorphin, enkephalin, g

Who reads Transmitter diversity in ganglion cells of the guinea pig gallbladder: An immunohistochemical study?

Author

Erin K. Talmage; Wendy A. Pouliot; Ellen B. Cornbrooks; Gary M. Mawe

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1992

Language

EN

Field

Neuroscience (Life Sciences)