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Optimisation of Frontal Chromatography by Partial Loading by Philippe Dantigny; Yuyan Wang; John Hubble; John A. Howell is a Chemistry article available to read on EtoBox.

What is Optimisation of Frontal Chromatography by Partial Loading about?

## Quantitative assessment of adsorbate losses during washing is used to provide the basis for a new approach to optimising the performance of packed-bed adsorption chromatography. This paper presents this new approach, and shows, through simulating the performance of the adsorption and washing processes how it can be used with a variety of performance criteria. These include: maximum use of column capacity, minimum product loss and maximum process throughput, The results show that for product loss to be minimised, it is advantageous to stop adsorption before column breakthrough is detected, in order to leave unused capacity capable of scavenging unadsorbed material and product eluted during the washing process. The effect of changes in axial dispersion, length of column loading, inherent adsorbent capacity and adsorption rate or mass transfer are analysed and discussed with respect to optimising the point at which washing is started. It is shown that the application of the new approach can improve column performance significantly and minimise waste without any serious consequence on column capacity utilisation and process throughput.

Who reads Optimisation of Frontal Chromatography by Partial Loading?

Author

Philippe Dantigny; Yuyan Wang; John Hubble; John A. Howell

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

1991

Language

EN

Field

Chemistry (Physical Sciences)