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What is GABAA Receptor Downregulation in Autism about?

This study investigated levels of GABAA receptor subunits in brain tissues from subjects with autism compared to controls. It found significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 subunits in the parietal cortex of subjects with autism. GABRA1 and GABRB3 were also significantly altered in the cerebellum, and GABRA1 was significantly altered in the superior frontal cortex of subjects with autism. The results suggest widespread GABAergic dysfunction in the brains of individuals with autism.

Author

aini qurrotullain

Language

EN