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Quantifying Tertiary Referral Center Bias in Vestibular Schwannoma Research by Elias S. Saba; John P. Marinelli; Christine M. Lohse; Michael J. Link; Matthew L. Carlson is a Medicine article available to read on EtoBox.

What is Quantifying Tertiary Referral Center Bias in Vestibular Schwannoma Research about?

## Objective: The majority of research influencing our understanding of vestibular schwannoma (VS) comes from large tertiary referral centers, and as a consequence, is inherently prone to referral bias. The objective of the current study was to characterize tertiary referral center bias in VS research. ## Study design: Single-institution retrospective clinical, audiometric, and radiologic review. ## Setting: One tertiary referral center. ## Patients: One hundred twenty-three patients with sporadic VS treated at our institution, consisting of a local cohort of all 41 VS patients residing in the same US county as our medical center and a referral cohort of 82 patients from outside counties matched 2:1 based on age, sex, and year of diagnosis. ## Intervention: Surgical resection, stereotactic radiosurgery (SRS), observation. ## Main outcome measures: Clinical manifestations, audiometric and radiologic findings, elected treatment modality. ## Results: Local patients had significantly longer follow-up after initial presentation compared to referral patients (median 4.0 vs 2.2 yr; p = 0.007). Referral patients were significantly less likely to have an incidental VS diagnosis (1% vs. 29%;

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Author
Elias S. Saba; John P. Marinelli; Christine M. Lohse; Michael J. Link; Matthew L. Carlson
Publisher
Lippincott Williams and Wilkins; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1537-4505)
Published
2019
Language
EN
Field
Medicine (Health Sciences)

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