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Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: A role for interleukin 10 by George D. Oreopoulos; Heshui Wu; Kati Szaszi; Jie Fan; John C. Marshall; Rachel G. Khadaroo; Ruijan He; Andras Kapus; Ori D. Rotstein is a Medicine article available to read on EtoBox.
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Ischemia/reperfusion (I/R) of the liver occurs in many clinical scenarios including trauma, elective surgery, and transplantation. Events initiated by this process can lead to inflammation in the liver, culminating in local injury as well as distant organ dysfunction. Recent studies have suggested that hypertonic saline exerts anti-inflammatory effects, which may be beneficial in preventing organ injury. In the present study, we examine the effect of hypertonic saline on the development of liver inflammation following I/R in both rat and mouse models. Hypertonic pretreatment was shown to prevent liver enzyme release concomitant with a reduction in liver neutrophil sequestration. Hypertonic saline appeared to exert this effect by inhibiting liver tumor necrosis factor ␣ (TNF-␣) generation, an effect that culminated in reduced liver adhesion molecule expression. Hypertonic saline pretreatment was shown to augment liver interleukin 10 (IL-10) expression following I/R, as a potential mechanism underlying its anti-inflammatory effect. To examine the role of IL-10 in the protective effect of hypertonic saline on liver I/R injury, we used a murine model of I/R. In wild type mice, hyperton
Who reads Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: A role for interleukin 10?
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- Author
- George D. Oreopoulos; Heshui Wu; Kati Szaszi; Jie Fan; John C. Marshall; Rachel G. Khadaroo; Ruijan He; Andras Kapus; Ori D. Rotstein
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)