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Oral Beclometasone Dipropionate in the Treatment of Active Ulcerative Colitis: a Double-blind Placebo-controlled Study by F. Rizzello; P. Gionchetti; A. D'Arienzo; F. Manguso; G. Di Matteo; V. Annese; D. Valpiani; T. Casetti; S. Adamo; A. Prada; G. N. Castiglione; G. Varoli; M. Campieri is a Medicine article available to read on EtoBox.
What is Oral Beclometasone Dipropionate in the Treatment of Active Ulcerative Colitis: a Double-blind Placebo-controlled Study about?
## Summary **Aim** : To evaluate efficacy and safety of oral beclometasone dipropionate (BDP) when added to 5‐ASA in the treatment of patients with active ulcerative colitis. **Methods** : In a 4‐week, placebo‐controlled, double‐blind study, patients with extensive or left‐sided mild to moderate active ulcerative colitis were randomized to receive oral 5‐ASA (3.2 g/day) plus BDP (5 mg/day) or placebo. Clinical, endoscopic and histologic features, and haematochemical parameters were recorded at baseline and at the end of the study. **Results** : One hundred and nineteen patients were enrolled and randomly treated with BDP plus 5‐ASA (__n__ = 58) or placebo plus 5‐ASA (__n__ = 61). Both treatment groups showed a statistically significant decrease of disease activity index (DAI) and histology score at the end of treatment (__P__ = 0.001, each). DAI score was lower in the BDP group than in the placebo group (__P__ = 0.014), with more patients in clinical remission in the BDP group (58.6% vs. 34.4%, __P__ = 0.008). Serum cortisol levels significantly decreased in BDP group vs. baseline (__P__ = 0.002), but without signs of pituitary‐adrenal function depletion. A low incidence of adverse
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- Author
- F. Rizzello; P. Gionchetti; A. D'Arienzo; F. Manguso; G. Di Matteo; V. Annese; D. Valpiani; T. Casetti; S. Adamo; A. Prada; G. N. Castiglione; G. Varoli; M. Campieri
- Publisher
- John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)