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Can I read Bombesin-like Peptide Receptor Gene Expression, Regulation, and Function in Fetal Murine Lung on EtoBox?
Bombesin-like Peptide Receptor Gene Expression, Regulation, and Function in Fetal Murine Lung by Lin Shan; Rodica L. Emanuel; Denise Dewald; John S. Torday; Nithiananthan Asokanathan; Keiji Wada; Etsuko Wada; Mary E. Sunday is a Medicine article available to read on EtoBox.
What is Bombesin-like Peptide Receptor Gene Expression, Regulation, and Function in Fetal Murine Lung about?
Bombesin-peptide (BLP) immunoreactivity occurs at high levels in fetal lung. Previous studies showed that bombesin promotes fetal lung development. To test the hypothesis that such effects are mediated by known mammalian bombesin receptors [gastrin-releasing peptide (GRP)/bombesin-preferring receptor (GRPR), neuromedin B (NMB) receptor (NMBR), and the orphan bombesin receptor subtype-3 (BRS-3)], we analyzed the ontogeny of GRPR, NMBR, and BRS-3 gene expression in mouse lung. We examined the regulation of these three genes by dexamethasone and bombesin, which modulate lung development. Using incorporation of [^3^H]thymidine and [^3^H]choline, we then assessed whether GRP, NMB, and Leu^8^-phyllolitorin modulate lung growth and maturation in fetal lung explants. GRPR gene expression was detected predominantly in utero, whereas NMBR and BRS-3 genes were expressed from embryonic days 13–16 and on multiple postnatal days. All three mRNAs are present in airway epithelium and mesenchymal cells but occur in different relative patterns. These genes were regulated differently. Dexamethasone and bombesin increased GRPR mRNA, bombesin downregulated NMBR, and neither agent affected BRS-3. GRP in
Who reads Bombesin-like Peptide Receptor Gene Expression, Regulation, and Function in Fetal Murine Lung?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lin Shan; Rodica L. Emanuel; Denise Dewald; John S. Torday; Nithiananthan Asokanathan; Keiji Wada; Etsuko Wada; Mary E. Sunday
- Publisher
- American Physiological Society
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)