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Coding repeat instability in the FLO11 gene of Saccharomyces yeasts by Manuel Fidalgo; Ramon R. Barrales; Juan Jimenez is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract In __Saccharomyces__ yeasts, the __FLO11__ gene encodes an adhesin involved in filamentation, invasive growth, flocculation and adherence to solid surfaces. In wild __Saccharomyces__ flor yeasts, a particularly expanded __FLO11__ allele also confers to these yeasts the ability to float under stressing liquid environments. We report here that, under optimal laboratory conditions, the repeats domain of the __FLO11__ gene in these wild yeasts is extremely unstable. Changes in length in the __FLO11__ coding repeats domain affected Flo11p‐associated functions but, interestingly, some of these functions were affected more than others. Therefore, length variations in this single gene provide a combinatorial diversity, which may contribute to a very rapid adaptation to fluctuating environments. Functional analysis of contracted alleles indicated that buoyancy was not associated to __FLO11__ length. In contrast, this property depended on the different types of repetitive units found in this gene. Thus, not only variations in the number of intragenic repeats but also the abundance and/or distribution of the different repetitive units may have phenotypic and evolutionary implicati

Who reads Coding repeat instability in the FLO11 gene of Saccharomyces yeasts?

Author

Manuel Fidalgo; Ramon R. Barrales; Juan Jimenez

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; [Chichester]; [New York]: John Wiley & Sons, ©1985-; Wiley; Hindawi Limited (ISSN 0749-503X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)