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Diversity of rotavirus genotypes circulating in children < 5 years of age hospitalized for acute gastroenteritis in India from 2005 to 2016: analysis of temporal and regional genotype variation by Sidhartha Giri; C. P. Girish Kumar; Shainey Alokit Khakha; Mamta Chawla-Sarkar; Varanasi Gopalkrishna; Shobha D. Chitambar; Pratima Ray; S. Venkatasubramanian; Biswa Jyoti Borkakoty; Subarna Roy; Jyothi Bhat; Bhagirathi Dwibedi; Pradeep Das; Vijayachari Paluru; Sasirekha Ramani; Sudhir Babji; Rashmi Arora; Sanjay M. Mehendale; Mohan D. Gupte; Gagandeep Kang; A. Agarwal; S. Aneja; Anna Simon; S. C. Aundhakar; A. Bavdekar; S. Baveja; D. Biswas; C. J. Bora; S. Chatterjee; S. Chaudhary; Das VNR; K. Desai; R. Dhongade; R. Dwivedi; K. Dzuvichu; N. Ganguly; G. Gathwala; C. Ghosh; D. S. Gupta; A. R. Jadhav; S. Jali; V. R. Kalrao; S. K. Kar; H. K. Khuntia; P. Kumar; S. S. Kumar; B. G. Lal; M. Manglani; B. Manohar; A. Mathew; M. A. Mathew; K. M. Mehariya; S. K. Mishra; S. Panda; K. Pandey; M. Patankar; C. S. Purani; G. C. Sahoo; N. Singh; P. Singh; T. Singh; S. Sundari; A. K. Thakur; R. K. Topno; A. Upadhyay; Utpalkant Singh; National Rotavirus Surveillance Network investigators is a Medicine article available to read on EtoBox.

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## Abstract ## Background From 2016, the Government of India introduced the oral rotavirus vaccine into the national immunization schedule. Currently, two indigenously developed vaccines (ROTAVAC, Bharat Biotech; ROTASIIL, Serum Institute of India) are included in the Indian immunization program. We report the rotavirus disease burden and the diversity of rotavirus genotypes from 2005 to 2016 in a multi-centric surveillance study before the introduction of vaccines. ## Methods A total of 29,561 stool samples collected from 2005 to 2016 (7 sites during 2005–2009, 3 sites from 2009 to 2012, and 28 sites during 2012–2016) were included in the analysis. Stools were tested for rotavirus antigen using enzyme immunoassay (EIA). Genotyping was performed on 65.8% of the EIA positive samples using reverse transcription- polymerase chain reaction (RT-PCR) to identify the G (VP7) and P (VP4) types. Multinomial logistic regression was used to quantify the odds of detecting genotypes across the surveillance period and in particular age groups. ## Results Of the 29,561 samples tested, 10,959 (37.1%) were positive for rotavirus. There was a peak in rotavirus positivity during December to February

Who reads Diversity of rotavirus genotypes circulating in children < 5 years of age hospitalized for acute gastroenteritis in India from 2005 to 2016: analysis of temporal and regional genotype variation?

Author

Sidhartha Giri; C. P. Girish Kumar; Shainey Alokit Khakha; Mamta Chawla-Sarkar; Varanasi Gopalkrishna; Shobha D. Chitambar; Pratima Ray; S. Venkatasubramanian; Biswa Jyoti Borkakoty; Subarna Roy; Jyothi Bhat; Bhagirathi Dwibedi; Pradeep Das; Vijayachari Paluru; Sasirekha Ramani; Sudhir Babji; Rashmi Arora; Sanjay M. Mehendale; Mohan D. Gupte; Gagandeep Kang; A. Agarwal; S. Aneja; Anna Simon; S. C. Aundhakar; A. Bavdekar; S. Baveja; D. Biswas; C. J. Bora; S. Chatterjee; S. Chaudhary; Das VNR; K. Desai; R. Dhongade; R. Dwivedi; K. Dzuvichu; N. Ganguly; G. Gathwala; C. Ghosh; D. S. Gupta; A. R. Jadhav; S. Jali; V. R. Kalrao; S. K. Kar; H. K. Khuntia; P. Kumar; S. S. Kumar; B. G. Lal; M. Manglani; B. Manohar; A. Mathew; M. A. Mathew; K. M. Mehariya; S. K. Mishra; S. Panda; K. Pandey; M. Patankar; C. S. Purani; G. C. Sahoo; N. Singh; P. Singh; T. Singh; S. Sundari; A. K. Thakur; R. K. Topno; A. Upadhyay; Utpalkant Singh; National Rotavirus Surveillance Network investigators

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)

Published

2020

Language

EN

Field

Medicine (Health Sciences)