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Biomarkers for predicting immune reconstitution inflammatory syndrome in dipeptidyl peptidase‐4 inhibitor‐associated bullous pemphigoid: A retrospective observational study with a case series by Sugiyama, Seiko (author);Yamamoto, Takenobu (author);Aoyama, Yumi (author) is a Medicine article available to read on EtoBox.
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## Abstract ## Background The prognosis of dipeptidyl peptidase‐4 inhibitor‐associated bullous pemphigoid (DPP‐4i‐BP) is variable, with some cases showing spontaneous remission after drug cessation and others showing worsening BP or developing infectious complications, termed infectious immune reconstitution inflammatory syndrome (IRIS), after DPP‐4i cessation. We recently demonstrated that the neutrophil‐to‐lymphocyte ratio measured at baseline and during treatment predicts the eventual development of infectious IRIS. ## Objectives To identify key molecular immune parameters that correlate with, and potentially shape, subsequent immune responses after DPP‐4i cessation. ## Methods This retrospective observational study examined DPP‐4i‐BP patients who were treated at our hospital for 4 years. Patients selected for this study were those who developed BP after initiation of DPP‐4i and were followed up at least 90 days after DPP‐4i cessation, if information and the relevant parameters were available from the medical records. The patients were divided into two cohorts: a spontaneous remission group and an exacerbation group showing worsening BP or developing infectious IRIS. Serum cytok
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- Author
- Sugiyama, Seiko (author);Yamamoto, Takenobu (author);Aoyama, Yumi (author)
- Publisher
- Wiley
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)
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