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Osteopenia, Excess Adiposity and Hyperleptinaemia During 2 Years of Treatment for Childhood Acute Lymphoblastic Leukaemia Without Cranial Irradiation by J. H. Davies; B. A. J. Evans; E. Jones; W. D. Evans; M. E. M. Jenney; J. W. Gregory is a Medicine article available to read on EtoBox.
What is Osteopenia, Excess Adiposity and Hyperleptinaemia During 2 Years of Treatment for Childhood Acute Lymphoblastic Leukaemia Without Cranial Irradiation about?
## Summary **objective** Osteopenia and excess adiposity occur following treatment of childhood acute lymphoblastic leukaemia (ALL) and the use of cranial irradiation is thought to be a significant contributory factor. Hyperleptinaemia has also been demonstrated following cessation of treatment for childhood ALL. Therefore a prospective study was undertaken to evaluate serial changes in percentage bone mineral content (BMC), adiposity and serum leptin concentrations during 2 years of treatment of children with ALL with chemotherapy but without cranial irradiation. **design and patient** Only patients treated using the MRC ALL 97/ALL 97 (modified 99) protocols for childhood ALL were eligible for entry into the study. A total of 14 patients (seven male, with a median age of 7·5 years (range 3·4–16·7 years) were recruited. Serial dual energy X‐ray absorptiometry (DEXA) scanning was undertaken at diagnosis and during two years of treatment. Serum leptin concentrations were determined at the same time as the scans. **results** Reductions in %BMC were observed at the hip and lumbar spine by 12 months (__P__ < 0·01) and remained low after 24 months of treatment. Subanalysis of %BMC measur
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- Author
- J. H. Davies; B. A. J. Evans; E. Jones; W. D. Evans; M. E. M. Jenney; J. W. Gregory
- Publisher
- Wiley
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)