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Can I read Mitochondrial Modulation of Intracellular Ca2+Signaling on EtoBox?
Mitochondrial Modulation of Intracellular Ca2+Signaling by CHRISTOPHER P. FALL; JOEL E. KEIZER is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mitochondrial Modulation of Intracellular Ca2+Signaling about?
IP3-mediated Ca> release plays a fundamental role in many cell signaling processes and has been the subject of numerous modeling studies. Only recently has the important role that mitochondria play in the dynamics of intracellular Ca> signaling begun to be considered in experimental work and in computational models. Mitochondria sequester large amounts of Ca> and thus have a modulatory e!ect on intracellular Ca> signaling, and mitochondrial uptake of Ca>, in turn, has a regulatory e!ect on mitochondrial function. Here we integrate a well-established model of IP3-mediated Ca> signaling with a detailed model of mitochondrial Ca> handling and metabolic function. The incorporation of mitochondria results in oscillations in a bistable formulation of the IP3 model, and increasing metabolic substrate decreases the frequency of these oscillations consistent with the literature. Ca> spikes from the cytosol are communicated into mitochondria and are shown to induce realistic metabolic changes. The model has been formulated using a modular approach that is easy to modify and should serve as a useful basis for the investigation of questions regarding the interaction of these two systems.
Who reads Mitochondrial Modulation of Intracellular Ca2+Signaling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- CHRISTOPHER P. FALL; JOEL E. KEIZER
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)