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Can I read The anti‐IgE/anti‐FcεRIα autoantibody network in allergic and autoimmune diseases on EtoBox?
The anti‐IgE/anti‐FcεRIα autoantibody network in allergic and autoimmune diseases by MARONE; SPADARO; PALUMBO; CONDORELLI is a Medicine article available to read on EtoBox.
What is The anti‐IgE/anti‐FcεRIα autoantibody network in allergic and autoimmune diseases about?
Basophil granulocytes and tissue mast cells and their mediators play a role in the pathogenesis of several immune and inflammatory disorders. Human basophils and mast cells (FcεRI^+^ cells) can be activated through immunological interaction with the IgE‐FcεRI network. FcεRI^+^ cells can be triggered by cross‐linking between the Fab portions of IgE and multivalent antigens (direct anaphylaxis). ‘Reverse type’ anaphylaxis can occur through three distinct mechanisms: antibodies against the Fcε portion of IgE (anti‐IgE), antibodies against epitopes of the α chain of FcεRI (anti‐FcεRIα) and anti‐IgG acting on IgG–IgE complexes bound to FcεRI. Anti‐IgE autoantibodies are occasionally present even in normal donors and more frequently in a variety of allergic (chronic urticaria, atopic dermatitis and bronchial asthma) and autoimmune disorders (rheumatoid arthritis, lupus erythematosus and systemic sclerosis). IgG anti‐IgE from a small percentage of patients induces the release of mediators from human FcεRI^+^ cells. Some of the anti‐IgE autoantibodies present in allergic patients are non‐anaphylactogenic, thus representing a possible protective mechanism preventing the association of IgE w
Who reads The anti‐IgE/anti‐FcεRIα autoantibody network in allergic and autoimmune diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- MARONE; SPADARO; PALUMBO; CONDORELLI
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)