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Genetic characterization of influenza A(H3N2) viruses from 2014 to 2017 in Yantai, east of China by Juan Liu; Lian-feng Gong; Zhen-lu Sun; Qiao Gao; Zhao-jing Dong is a Medicine article available to read on EtoBox.

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## Abstract ## Background: The genetic variations of influenza viruses pose a real challenge to the vaccine strategies and medical treatment of patients. ## Methods: In this study, the molecular epidemiology and evolution of influenza A(H3N2) strains were analyzed from April 2014 to March 2017 in Yantai area of eastern China. ## Results: The phylogenetic analysis of the hemagglutinin (HA) sequences of influenza A(H3N2) showed that all of the influenza A(H3N2) strains during the study period belonged to the genetic clade 3c with the mutations N145S (epitopeA), V186G (epitopeB), P198S (epitopeB) and F219S (epitopeD). Most strains (12/14) of the 2014/2015 season fell into the subgroup 3C.3a characterized by A138S (epitopeA), R142G (epitopeA), F159S (epitopeB) and T128A (epitopeB), while strains isolated from the 2015/2016 and 2016/2017 seasons clustered in 3C.2a shared mutations N144S (epitopeA), F159Y (epitopeB), K160T (epitopeB) and Q311H (epitopeC). The strains isolated from the 2014/2015 and 2015/2016 seasons was were genetically and antigenically distinct from the given vaccine strains. The evaluation of vaccine efficacy (VE) against circulating strains estimated using the pepito

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Author

Juan Liu; Lian-feng Gong; Zhen-lu Sun; Qiao Gao; Zhao-jing Dong

Publisher

Walter de Gruyter GmbH

Published

2018

Language

EN

Field

Medicine (Health Sciences)