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Immunotherapy Affects the Seasonal Increase in Specific IgE and Interleukin-4 in Serum of Patients with Seasonal Allergic Rhinitis by Y. OHASHI; Y. NAKAI; Y. KAKINOKI; Y. OHNO; A. TANAKA; T. MASAMOTO; H. SAKAMOTO; Y. WASHIO; A. KATO is a Immunology and Microbiology article available to read on EtoBox.

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This study was designed to determine seasonal changes in cytokines, soluble CD23 and specific IgE in the serum of patients with seasonal allergic rhinitis, and the effect of immunotherapy on these seasonal changes. Fifty‐four patients with seasonal allergic rhinitis caused by Japanese cedar pollens were divided into a medication group and an immunotherapy group. The patients of the medication group were treated with non‐sedating antihistamines alone during the pollen season. The patients of the immunotherapy group had been treated for variable periods (mean, 5.0 ± 3.2 years) with immunotherapy using Japanese cedar pollen antigens. Serum samples were collected before and during the pollen season from each patient, to determine specific IgE, interleukin‐4 (IL‐4), interferon‐γ (IFN‐γ) and soluble CD23 levels in serum. A significant increase in specific IgE and IL‐4 and a significant decrease in IFN‐γ were observed during the pollen season in the medication group. In contrast, in the immunotherapy group, none of specific IgE, IL‐4 and IFN‐γ was significantly changed following natural exposure to pollens. However, these effects were not significant in patients undergoing immunotherapy f

Who reads Immunotherapy Affects the Seasonal Increase in Specific IgE and Interleukin-4 in Serum of Patients with Seasonal Allergic Rhinitis?

Author

Y. OHASHI; Y. NAKAI; Y. KAKINOKI; Y. OHNO; A. TANAKA; T. MASAMOTO; H. SAKAMOTO; Y. WASHIO; A. KATO

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0300-9475)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)