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Entrapment of Islets Into Reversible Disulfide Hydrogels by Nobuharu Hisano; Noriyuki Morikawa; Hiroo Iwata; Yoshito Ikada is a Medicine article available to read on EtoBox.

What is Entrapment of Islets Into Reversible Disulfide Hydrogels about?

Currently, there are three types of devices for a bioartificial pancreas; microencapsulation, an extravascular diffusion chamber, and an intravascular diffusion chamber. The purpose of the present study was to provide a new extracellular matrix hydrogel for the devices of extra-and intravascular diffusion chamber types. As the sol-gel transition of this hydrogel is reversible, refilling of islets in vivo will be possible without a severe traumatic procedure. The hydrogel was produced from a polyacrylamide derivative carrying thiol groups synthesized by radical copolymerization of acrylamide and N,NЈ-bis-acrylcystamine, followed by reduction of the disulfide bonds in the copolymer. This wa-ter-soluble copolymer was used to entrap hamster islets by re-formation of disulfide bonds on the copolymer to produce a hydrogel. The formed hydrogel was easily reliquefied by reduction of the disulfide crosslinks to thiols. Insulin release from the islet-entrapped hydrogel continued for more than 1 month when examined in vitro. A static glucose stimulation test for the entrapped islets exhibited an increased insulin release.

Who reads Entrapment of Islets Into Reversible Disulfide Hydrogels?

Author

Nobuharu Hisano; Noriyuki Morikawa; Hiroo Iwata; Yoshito Ikada

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1998

Language

EN

Field

Medicine (Health Sciences)