Can I read Networks of Resistance: Small RNA Control of Antibiotic Resistance on EtoBox?

Networks of Resistance: Small RNA Control of Antibiotic Resistance by Daniel G. Mediati; Sylvania Wu; Winton Wu; Jai J. Tree is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Networks of Resistance: Small RNA Control of Antibiotic Resistance about?

The golden age of antibiotics has passed, and the threat of untreatable antimicrobial resistant infections is now a reality for many individuals. Understanding how bacteria resist antimicrobial treatment and regulate gene expression in response to antibiotics is an important step towards combating resistance. In this review we focus on a ubiquitous class of bacterial gene regulators termed regulatory small RNAs (sRNAs) and how they contribute to antimicrobial resistance and tolerance. Small RNAs have notable roles in modulating the composition of the bacterial envelope, and through these functions control intrinsic antimicrobial resistance in many human pathogens. Recent technical advances that allow profiling of the 'sRNA interactome' have revealed a complex post-transcriptional network of sRNA interactions that can be used to identify network hubs and regulatory bottlenecks. Sequence-specific inhibition of these sRNAs with programmable RNA-targeting therapeutics may present avenues for treating antimicrobial resistant pathogens or resensitizing to our current antibiotics.

Who reads Networks of Resistance: Small RNA Control of Antibiotic Resistance?

Author

Daniel G. Mediati; Sylvania Wu; Winton Wu; Jai J. Tree

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0168-9525)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)