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Whole transcriptome–based skin virome profiling in typical epidermodysplasia verruciformis reveals **α**-, **β**-, and **γ**-HPV infections by Amir Hossein Saeidian; Leila Youssefian; Mahtab Naji; Hamidreza Mahmoudi; Samantha M. Barnada; Charles Huang; Karim Naghipoor; Amir Hozhabrpour; Jason S. Park; Flavia Manzo Margiotta; Fatemeh Vahidnezhad; Zahra Saffarian; Kambiz Kamyab-Hesari; Mohammad Tolouei; Niloofar Faraji; Seyyede Zeinab Azimi; Ghazal Namdari; Parvin Mansouri; Jean-Laurent Casanova; Vivien Béziat; Emmanuelle Jouanguy; Jouni Uitto; Hassan Vahidnezhad is a Immunology and Microbiology article available to read on EtoBox.

What is Whole transcriptome–based skin virome profiling in typical epidermodysplasia verruciformis reveals **α**-, **β**-, and **γ**-HPV infections about?

HPVs are DNA viruses include approximately 450 types that are classified into 5 genera (α-, β-, γ-, μ-, and ν-HPV). The γ- and β-HPVs are present in low copy numbers in healthy individuals; however, in patients with an inborn error of immunity, certain species of β-HPVs can cause epidermodysplasia verruciformis (EV), manifesting as recalcitrant cutaneous warts and skin cancer. EV presents as either typical or atypical. Manifestations of typical EV are limited to the skin and are caused by abnormal keratinocyte-intrinsic immunity to β-HPVs due to pathogenic sequence variants in __TMC6__, __TMC8__, or __CIB1__. We applied a transcriptome-based computational pipeline, VirPy, to RNA extracted from normal-appearing skin and wart samples of patients with typical EV to explore the viral and human genetic determinants. In 26 patients, 9 distinct biallelic mutations were detected in __TMC6__, __TMC8__, and __CIB1__, 7 of which are previously unreported to our knowledge. Additionally, 20 different HPV species, including 3 α-HPVs, 16 β-HPVs, and 1 γ-HPV, were detected, 8 of which are reported here for the first time to our knowledge in patients with EV (β-HPV-37, -47, -80, -151, and -159; α-H

Who reads Whole transcriptome–based skin virome profiling in typical epidermodysplasia verruciformis reveals **α**-, **β**-, and **γ**-HPV infections?

Author

Amir Hossein Saeidian; Leila Youssefian; Mahtab Naji; Hamidreza Mahmoudi; Samantha M. Barnada; Charles Huang; Karim Naghipoor; Amir Hozhabrpour; Jason S. Park; Flavia Manzo Margiotta; Fatemeh Vahidnezhad; Zahra Saffarian; Kambiz Kamyab-Hesari; Mohammad Tolouei; Niloofar Faraji; Seyyede Zeinab Azimi; Ghazal Namdari; Parvin Mansouri; Jean-Laurent Casanova; Vivien Béziat; Emmanuelle Jouanguy; Jouni Uitto; Hassan Vahidnezhad

Publisher

American Society for Clinical Investigation

Published

2023

Language

EN

Field

Immunology and Microbiology (Life Sciences)