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Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart by Diana Bou-Teen; Nina Kaludercic; David Weissman; Belma Turan; Christoph Maack; Fabio Di Lisa; Marisol Ruiz-Meana is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart about?

Excessive mitochondrial ROS production has been causally linked to the pathophysiology of aging in the heart and other organs, and plays a deleterious role in several age-related cardiac pathologies, including myocardial ischemia-reperfusion injury and heart failure, the two worldwide leading causes of death and disability in the elderly. However, ROS generation is also a fundamental mitochondrial function that orchestrates several signaling pathways, some of them exerting cardioprotective effects. In cardiac myocytes, mitochondria are particularly abundant and are specialized in subcellular populations, in part determined by their relationships with other organelles and their cyclic calcium handling activity necessary for adequate myocardial contraction/ relaxation and redox balance. Depending on their subcellular location, mitochondria can themselves be differentially targeted by ROS and display distinct age-dependent functional decline. Thus, precise mitochondriatargeted therapies aimed at counteracting unregulated ROS production are expected to have therapeutic benefits in certain aging-related heart conditions. However, for an adequate design of such therapies, it is necessary

Who reads Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart?

Author

Diana Bou-Teen; Nina Kaludercic; David Weissman; Belma Turan; Christoph Maack; Fabio Di Lisa; Marisol Ruiz-Meana

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)