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Can I read Emergence of Gold‐Mesoporous Silica Hybrid Nanotheranostics: Dox‐Encoded, Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication on EtoBox?
Emergence of Gold‐Mesoporous Silica Hybrid Nanotheranostics: Dox‐Encoded, Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication by Adukkadan N. Ramya; Manu M. Joseph; Santhi Maniganda; Varsha Karunakaran; Sreelekha T. T.; Kaustabh Kumar Maiti is a Engineering article available to read on EtoBox.
What is Emergence of Gold‐Mesoporous Silica Hybrid Nanotheranostics: Dox‐Encoded, Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication about?
Strategically fabricated theranostic nanocarrier delivery system is an unmet need in personalized medicine. Herein, this study reports a versatile folate receptor (FR) targeted nanoenvelope delivery system (TNEDS) fabricated with gold core silica shell followed by chitosan–folic acid conjugate surface functionalization by for precise loading of doxorubicin (Dox), resembled as Au@SiO~2~‐Dox‐CS‐FA. TNEDS possesses up to 90% Dox loading efficiency and internalized through endocytosis pathway leading to pH and redox‐sensitive release kinetics. The superior FR‐targeted cytotoxicity is evaluated by the nanocarrier in comparison with US Food and Drug Administration (FDA)‐approved liposomal Dox conjugate, Lipodox. Moreover, TNEDS exhibits theranostic features through caspase‐mediated apoptosis and envisages high surface plasmon resonance enabling the nanoconstruct as a promising surface enhanced Raman scattering (SERS) nanotag. Minuscule changes in the biochemical components inside cells exerted by the TNEDS along with the Dox release are evaluated explicitly in a time‐dependent fashion using bimodal SERS/fluorescence nanoprobe. Finally, TNEDS displays superior antitumor response in FR‐pos
Who reads Emergence of Gold‐Mesoporous Silica Hybrid Nanotheranostics: Dox‐Encoded, Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Adukkadan N. Ramya; Manu M. Joseph; Santhi Maniganda; Varsha Karunakaran; Sreelekha T. T.; Kaustabh Kumar Maiti
- Publisher
- Wiley
- Published
- 2017
- Language
- EN
- Field
- Engineering (Physical Sciences)