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Can I read A high-throughput test to detect C.E.R.A. doping in blood on EtoBox?
A high-throughput test to detect C.E.R.A. doping in blood by Séverine Lamon; Sylvain Giraud; Léonie Egli; Jessica Smolander; Michael Jarsch; Kay-Gunnar Stubenrauch; Alice Hellwig; Martial Saugy; Neil Robinson is a Chemistry article available to read on EtoBox.
What is A high-throughput test to detect C.E.R.A. doping in blood about?
C.E.R.A., a continuous erythropoietin receptor activator, is a new third-generation erythropoiesisstimulating agent (ESA) that has recently been linked with abuse in endurance sports. In order to combat this new form of doping, we examined an enzyme-linked immunosorbent assay (ELISA) designed to detect the presence of C.E.R.A. in serum samples. The performance of the assay was evaluated using a pilot excretion study that involved six subjects receiving C.E.R.A. Validation data demonstrated an excellent reproducibility and ensured the applicability of the assay for anti-doping purposes. To maximize the chances of detecting the drug in serum samples, we propose the use of this specific ELISA test as a high-throughput screening method, combined with a classic isoelectric focusing test as a confirmatory assay. This strategy should make C.E.R.A. abuse relatively easy to detect, thereby preventing the future use of this drug as a doping agent.
Who reads A high-throughput test to detect C.E.R.A. doping in blood?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Séverine Lamon; Sylvain Giraud; Léonie Egli; Jessica Smolander; Michael Jarsch; Kay-Gunnar Stubenrauch; Alice Hellwig; Martial Saugy; Neil Robinson
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2009
- Language
- EN
- Field
- Chemistry (Physical Sciences)