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Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine: Future outlook by Oleksandr (Alexander) Petrenko; Olga Prokopyuk; Oleg Nardid; Yuriy Petrenko is a Medicine article available to read on EtoBox.

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Although the first CPA (glycerol) was discovered in 1949 and the development of Me 2 SO occurred over 60 years ago, we have only recently learned that high subzero ( -20 C) preservation (either in a supercooled or partially frozen state) can significantly increase storage times (3-6 fold or more in organs) over simple hypothermia (< 1 day) while avoiding traditional problems of toxicity and chilling injury. Likewise, low subzero preservation (or vitrification) (< -140 C) effectively stops biological time and can be achieved by using either extremely rapid cooling rates or high concentrations of CPA cocktails. Isochoric (or constant volume) systems have the potential to precisely control ice formation and, in some cases, even eliminate the need for high CPA concentrations. The Figure below captures the range of preservation temperatures being used by several groups world-wide. We will also review new rewarming technologies to bring chilled and vitrified organs back for transplant or biomedical use.

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Author

Oleksandr (Alexander) Petrenko; Olga Prokopyuk; Oleg Nardid; Yuriy Petrenko

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)