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A comparative study of in-vitro and in-silico anti-candidal activity and GC–MS profiles of snow mountain garlic vs. normal garlic by Bhupinder Kaur; Nitish Kumar; Sonam Chawla; Deepika Sharma; Suresh Korpole; Rajni Sharma; Manoj K. Patel; Kanwaljit Chopra; Om Prakash Chaurasia; Shweta Saxena is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A comparative study of in-vitro and in-silico anti-candidal activity and GC–MS profiles of snow mountain garlic vs. normal garlic about?
## Aim: The study aimed to profile the volatile phytocomposition of snow mountain garlic (smg) compared to normal garlic and investigate the anti-candida efficacy against clinically relevant multi-drug resistant isolates of candida species. ## Methods and results: Herein, smg has shown significantly superior fungicidal power at 2x-mic dose against c. albicans and c. glabrata in killing kinetic evaluation unlike the fungistatic effect of normal garlic. gc-ms headspace-based profiling of smg showed 5 unique volatile compounds and a 5-fold higher content of saponins than normal garlic. in an in-silico analysis, cholesta-4,6-dien-3-ol,(3-beta) was uniquely identified in smg as a potential inhibitor with high binding affinity to the active site of exo-1,3-betaglucan synthase, an established anti-candida drug target crucial for the biofilm matrix formation, thus suggesting a plausible anti-candida mechanism. ## Conclusion: The in-vitro and in-silico studies have demonstrated the candida-cidal and anti-biofilm activities of smg, distinguishing it from the candida-static efficacy of normal garlic. ## Significance and impact of the study: This is the first report that identifies several phy
Who reads A comparative study of in-vitro and in-silico anti-candidal activity and GC–MS profiles of snow mountain garlic vs. normal garlic?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Bhupinder Kaur; Nitish Kumar; Sonam Chawla; Deepika Sharma; Suresh Korpole; Rajni Sharma; Manoj K. Patel; Kanwaljit Chopra; Om Prakash Chaurasia; Shweta Saxena
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)