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Protein interaction networks of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster: Large-scale organization and robustness by Dong Li; Jianqi Li; Shuguang Ouyang; Jian Wang; Songfeng Wu; Ping Wan; Yunping Zhu; Xiaojie Xu; Fuchu He is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Protein interaction networks of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster: Large-scale organization and robustness about?
## Abstract High‐throughput screens have begun to reveal protein interaction networks in several organisms. To understand the general properties of these protein interaction networks, a systematic analysis of topological structure and robustness was performed on the protein interaction networks of __Saccharomyces cerevisiae__, __Caenorhabditis elegans__ and __Drosophila melanogaster__. It shows that the three protein interaction networks have a scale‐free and high‐degree clustering nature as the consequence of their hierarchical organization. It also shows that they have the small‐world property with similar diameter at 4–5. Evaluation of the consequences of random removal of both proteins and interactions from the protein interaction networks suggests their high degree of robustness. Simulation of a protein's removal shows that the protein interaction network's error tolerance is accompanied by attack vulnerability. These fundamental analyses of the networks might serve as a starting point for further exploring complex biological networks and the coming research of “systems biology”.
Who reads Protein interaction networks of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster: Large-scale organization and robustness?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dong Li; Jianqi Li; Shuguang Ouyang; Jian Wang; Songfeng Wu; Ping Wan; Yunping Zhu; Xiaojie Xu; Fuchu He
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)