Can I read Applications of the Chick Chorioallantoic Membrane as an Alternative Model for Cancer Studies on EtoBox?

Applications of the Chick Chorioallantoic Membrane as an Alternative Model for Cancer Studies by Pei-Yu Chu; Angele Pei-Fern Koh; Jane Antony; Ruby Yun-Ju Huang is a Medicine article available to read on EtoBox.

What is Applications of the Chick Chorioallantoic Membrane as an Alternative Model for Cancer Studies about?

A variety of in vivo experimental models have been established for the studies of human cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet the aspiration of precision medicine, the in vivomurine models have been widely adopted. However, common constraints such as high cost, long duration of experiments, and low engraftment efficiency remained to be resolved. The chick embryo chorioallantoic membrane (CAM) is an alternative model to overcome some of these limitations. Here, we provide an overview of the applications of the chick CAM model in the study of oncology. The CAM model has shown significant retention of tumor heterogeneity alongside increased xenograft take rates in several PDX studies. Various imaging techniques and data analysis have been applied to study tumor metastasis, angiogenesis, and therapeutic response to novel agents. Lastly, to practically illustrate the feasibility of utilizing the CAM model, we summarize the general protocol used in a case study utilizing an ovarian cancer PDX.

Who reads Applications of the Chick Chorioallantoic Membrane as an Alternative Model for Cancer Studies?

Author

Pei-Yu Chu; Angele Pei-Fern Koh; Jane Antony; Ruby Yun-Ju Huang

Publisher

S. Karger AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)