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Can I read Advantage of the Mark-III FEL for biophysical research and biomedical applications on EtoBox?
Advantage of the Mark-III FEL for biophysical research and biomedical applications by Glenn S. Edwards; M. Shane Hutson is a Physics and Astronomy article available to read on EtoBox.
What is Advantage of the Mark-III FEL for biophysical research and biomedical applications about?
Although 6.45 mm is not the strongest absorption band of biological tissues in the mid-infrared, a Mark-III free-electron laser (FEL) tuned to this wavelength can ef®ciently ablate tissue while minimizing collateral damage. A model has previously been presented that explains this wavelength dependence as a competition between two dynamic processes ± explosive vaporization of saline and denaturation of structural proteins. Here it is shown that this model predicts a `sweet-spot' for each wavelength, i.e. a region of parameter space (incident intensity and pulse width) in which explosive vaporization is preceded by substantial protein denaturation. This sweet-spot is much larger for wavelengths where protein is the dominant chromophore. At other wavelengths, collateral damage may be minimized within the sweet-spot, but the maximum intensities and pulse widths in these regions are insuf®cient to remove tissue at surgically relevant rates.
Who reads Advantage of the Mark-III FEL for biophysical research and biomedical applications?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Glenn S. Edwards; M. Shane Hutson
- Publisher
- International Union of Crystallography; Blackwell Publishing Inc.; International Union of Crystallography (IUCr) (ISSN 0909-0495)
- Published
- 2003
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)