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A Comparison of Oxidative Stress in Smokers and Non-smokers: an in Vivo Human Quantitative Study of N -3 Lipid Peroxidation by Basant K Puri; Ian H Treasaden; Massimo Cocchi; Sofia Tsaluchidu; Lucio Tonello; Brian M Ross is a Psychology article available to read on EtoBox.

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## Background Cigarette smoking is believed to cause oxidative stress by several mechanisms, including direct damage by radical species and the inflammatory response induced by smoking, and would therefore be expected to cause increased lipid peroxidation. The aim was to carry out the first study of the relationship of smoking in humans to the level of __n__-3 lipid peroxidation indexed by the level of ethane in exhaled breath. ## Methods Samples of alveolar air were obtained from 11 smokers and 18 non-smokers. The air samples were analyzed for ethane using mass spectrometry. ## Results The two groups of subjects were matched with respect to age and gender. The mean cumulative smoking status of the smokers was 11.8 (standard error 2.5) pack-years. The mean level of ethane in the alveolar breath of the group of smokers (2.53 (0.55) ppb) was not significantly different from that of the group of non-smokers (2.59 (0.29) ppb; __p__ = 0.92). With all 29 subjects included, the Spearman rank correlation coefficient between ethane levels and cumulative smoking status was -0.11 (__p__ = 0.58), while an analysis including only the smokers yielded a corresponding correlation coefficient of 0.

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Author

Basant K Puri; Ian H Treasaden; Massimo Cocchi; Sofia Tsaluchidu; Lucio Tonello; Brian M Ross

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-244X)

Published

2008

Language

EN

Field

Psychology (Social Sciences)