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Can I read Modulation of radiation-induced damage of human glomerular endothelial cells by SMPDL3B on EtoBox?

Modulation of radiation-induced damage of human glomerular endothelial cells by SMPDL3B by Abou Daher, Alaa; Francis, Marina; Azzam, Patrick; Ahmad, Anis; Eid, Assaad A.; Fornoni, Alessia; Marples, Brian; Zeidan, Youssef H. is a Medicine article available to read on EtoBox.

What is Modulation of radiation-induced damage of human glomerular endothelial cells by SMPDL3B about?

The intracellular molecular pathways involved in radiation-induced nephropathy are still poorly understood. Glomerular endothelial cells are key components of the structure and function of the glomerular filtration barrier but little is known about the mechanisms implicated in their injury and repair. The current study establishes the response of immortalized human glomerular endothelial cells (GEnC) to ionizing radiation (IR). We investigated the role of sphingolipids and the lipid-modifying enzyme sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) in radiation-induced GEnC damage. After delivering a single dose of radiation, long and very-long-chain ceramide species, and the expression levels of SMPDL3b were elevated. In contrast, levels of ceramide-1-phosphate (C1P) dropped in a time-dependent manner although mRNA and protein levels of ceramide kinase (CERK) remained stable. Treatment with C1P or knocking down SMPDL3b partially restored cell survival and conferred radioprotection. We also report a novel role for the NADPH oxidase enzymes (NOXs), namely NOX1, and NOX-derived reactive oxygen species (ROS) in radiation-induced GEnC damage. Subjecting cultured endothelial cells

Who reads Modulation of radiation-induced damage of human glomerular endothelial cells by SMPDL3B?

It is typically read by researchers, students, and practitioners in Medicine.

Author
Abou Daher, Alaa; Francis, Marina; Azzam, Patrick; Ahmad, Anis; Eid, Assaad A.; Fornoni, Alessia; Marples, Brian; Zeidan, Youssef H.
Publisher
The Federation of American Societies for Experimental Biology; Federation of American Society for Experimental Biology; Federation of American Societies for Experimental Biology; Wiley; FASEB (ISSN 0892-6638)
Published
2020
Language
EN
Field
Medicine (Health Sciences)

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