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Pro-inflammatory Cytokines Downregulate Platelet Derived Growth Factor-α Receptor Gene Expression in Human Osteoblastic Cells by Kemal N. Kose; Jing-Feng Xie; David L. Carnes; Dana T. Graves is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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1988). PDGF is the prototypical wound healing hormone. There are two different PDGF polypeptides that are 56% homologous and encoded by different genes. The PDGF-A and PDGF-B genes are independently regulated. PDGF exists as three different dimers of these gene products; PDGF-AA, PDGF-BB, and PDGF-AB. There are also two different PDGF receptors: the PDGF alpha receptor (binds PDGF-AA, PDGF-BB and PDGF-AB) and the PDGF-beta receptor (binds PDGF-BB and PDGF-AB) (Seifert et al., 1989; Matsui et al., 1989). The capacity of a cell to respond to PDGF-AA will depend specifically upon the number of PDGF alpha receptors, while the capacity to respond to PDGF-BB is dependent upon the number of either alpha or beta receptors . Support for the importance for PDGF in osseous metabolism comes from our studies and studies by others indicating that: (1) PDGF stimulates mitogenesis and migration in osteoblastic cells

Who reads Pro-inflammatory Cytokines Downregulate Platelet Derived Growth Factor-α Receptor Gene Expression in Human Osteoblastic Cells?

Author

Kemal N. Kose; Jing-Feng Xie; David L. Carnes; Dana T. Graves

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)