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Formyl peptide stimulation of superoxide anion release from lung macrophages: Sodium and potassium involvement by Andrij Holian; Ronald P. Daniele is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract We examined the role of the monovalent cations Na^+^ and K^+^ in the events encompassing the release of O by alveolar macrophages after stimulation with formyl methionyl phenylalanine (FMP). This was accomplished by determining the effect of changing the extracellular [Na^+^] and/or [K^+^] on FMP‐stimulated O production; and measuring ^22^Na^+^ ^42^K^+^ and ^86^Rb^+^ influx and efflux and intracellular [K^+^] for control and FMP‐stimulated alveolar macrophages. Stimulated O production was relatively insensitive to changes in extracellular K^+^ or Na^+^ concentrations until the [Na^+^] was decreased below 35 mM. At 4 mM [Na^+^], the rate of O production remained at 75% of the maximal rate observed at physiological concentrations of [Na^+^]. Both influx and efflux of ^22^Na^+^ were stimulated above control rates by FMP. The increased rates of fluxes lasted for a few minutes suggesting a transient increase in membrane permeability to Na^+^. Ouabain partially inhibited ^22^Na^+^ efflux but had no effect on O release. The influx of ^86^Rb^+^ and ^42^K^+^ was not altered by the addition of FMP but was virtually abolished in the presence of 10 μM ouabain or 1 mM quinine. In th

Who reads Formyl peptide stimulation of superoxide anion release from lung macrophages: Sodium and potassium involvement?

Author

Andrij Holian; Ronald P. Daniele

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1982

Language

EN

ISBN

9781041130307

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)