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Multi-moded High-index Contrast Optical Waveguide for Super-contrast High-resolution Label-free Microscopy by Nikhil Jayakumar; Firehun T. Dullo; Vishesh Dubey; Azeem Ahmad; Florian Ströhl; Jennifer Cauzzo; Eduarda Mazagao Guerreiro; Omri Snir; Natasa Skalko-Basnet; Krishna Agarwal; Balpreet Singh Ahluwalia is a Engineering article available to read on EtoBox.
What is Multi-moded High-index Contrast Optical Waveguide for Super-contrast High-resolution Label-free Microscopy about?
## Abstract The article elucidates the physical mechanism behind the generation of superior-contrast and high-resolution label-free images using an optical waveguide. Imaging is realized by employing a high index contrast multi-moded waveguide as a partially coherent light source. The modes provide near-field illumination of unlabeled samples, thereby repositioning the higher spatial frequencies of the sample into the far-field. These modes coherently scatter off the sample with different phases and are engineered to have random spatial distributions within the integration time of the camera. This mitigates the coherent speckle noise and enhances the contrast (2–10) × as opposed to other imaging techniques. Besides, the coherent scattering of the different modes gives rise to fluctuations in intensity. The technique demonstrated here is named chip-based Evanescent Light Scattering (cELS). The concepts introduced through this work are described mathematically and the high-contrast image generation process using a multi-moded waveguide as the light source is explained. The article then explores the feasibility of utilizing fluctuations in the captured images along with fluorescence-b
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- Author
- Nikhil Jayakumar; Firehun T. Dullo; Vishesh Dubey; Azeem Ahmad; Florian Ströhl; Jennifer Cauzzo; Eduarda Mazagao Guerreiro; Omri Snir; Natasa Skalko-Basnet; Krishna Agarwal; Balpreet Singh Ahluwalia
- Publisher
- De Gruyter
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)