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Anakinra in hospitalized non-intubated patients with coronavirus disease 2019: a Systematic review and meta-analysis by Fotios Barkas; Sebastian Filippas-Ntekouan; Maria Kosmidou; Evangelos Liberopoulos; Angelos Liontos; Haralampos Milionis is a Medicine article available to read on EtoBox.

What is Anakinra in hospitalized non-intubated patients with coronavirus disease 2019: a Systematic review and meta-analysis about?

## Abstract ## Objectives Acute respiratory distress syndrome and cytokine release syndrome are the major complications of coronavirus disease 2019 (COVID-19) associated with increased mortality risk. We performed a meta-analysis to assess the efficacy and safety of anakinra in adult hospitalized non-intubated patients with COVID-19. ## Methods Relevant trials were identified by searching literature until 24 April 2021 using the following terms: anakinra, IL-1, coronavirus, COVID-19, SARS-CoV-2. Trials evaluating the effect of anakinra on the need for invasive mechanical ventilation and mortality in hospitalized non-intubated patients with COVID-19 were included. ## Results Nine studies (n = 1119) were eligible for inclusion in the present meta-analysis. Their bias risk with reference to the assessed parameters was high. In pooled analyses, anakinra reduced the need for invasive mechanical ventilation (odds ratio (OR): 0.38, 95% CI: 0.17–0.85, P = 0.02, I2 = 67%; six studies, n = 587) and mortality risk (OR: 0.32, 95% CI: 0.23–0.45, P 0.05, I2 = 28%; five studies, n = 591) and bacteraemia (OR: 1.07, 95% CI: 0.42–2.73, P > 0.05, I2 = 71%; six studies, n = 727). ## Conclusions Avai

Who reads Anakinra in hospitalized non-intubated patients with coronavirus disease 2019: a Systematic review and meta-analysis?

Author

Fotios Barkas; Sebastian Filippas-Ntekouan; Maria Kosmidou; Evangelos Liberopoulos; Angelos Liontos; Haralampos Milionis

Publisher

Oxford University Press (OUP)

Published

2021

Language

EN

Field

Medicine (Health Sciences)