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Factors Associated with Local Recurrence and Cause-specific Survival in Patients with Ductal Carcinoma in Situ of the Breast Treated with Breast-conserving Therapy or Mastectomy by Carlos Vargas; Larry Kestin; Nel Go; Daniel Krauss; Peter Chen; Neal Goldstein; Alvaro Martinez; Frank A. Vicini is a Medicine article available to read on EtoBox.

What is Factors Associated with Local Recurrence and Cause-specific Survival in Patients with Ductal Carcinoma in Situ of the Breast Treated with Breast-conserving Therapy or Mastectomy about?

## Purpose: We reviewed our institution's experience treating patients with ductal carcinoma in situ (dcis) of the breast to determine risk factors for ipsilateral breast tumor recurrence (ibtr) and cause-specific survival (css) after breast-conserving therapy (bct) or mastectomy. ## Materials and methods: Between 1981 and 1999, 410 cases of dcis (405 patients) were treated at our institution; 367 were managed with breast-conserving surgery (54 with lumpectomy alone and 313 with adjuvant radiation therapy (rt) [median dose, 45 gy]). of these 313 patients, 298 received also a supplemental boost of rt to the lumpectomy cavity (median dose, 16 gy). forty-three patients underwent mastectomy; 2 (5%) received adjuvant rt to the chest wall. a true recurrence/marginal miss (tr/mm) ibtr was defined as failure within or adjacent to the tumor bed in patients undergoing bct. median follow-up for all patients was 7 years (mean: 6.1 years). ## Results: Thirty patients (8.2%) experienced an ibtr after bct (25 [8%] after rt, 5 [9.3%] after no rt), and 2 patients (4.7%) developed a chest wall recurrence after mastectomy. of the 32 local failures, 20 (63%) were invasive (18/30 [60%] after bct and 2/

Who reads Factors Associated with Local Recurrence and Cause-specific Survival in Patients with Ductal Carcinoma in Situ of the Breast Treated with Breast-conserving Therapy or Mastectomy?

Author

Carlos Vargas; Larry Kestin; Nel Go; Daniel Krauss; Peter Chen; Neal Goldstein; Alvaro Martinez; Frank A. Vicini

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2005

Language

EN

Field

Medicine (Health Sciences)