Can I read 4. Brain Default Mode Network Connectivity and Familial Risk of Major Mood Disorders on EtoBox?

4. Brain Default Mode Network Connectivity and Familial Risk of Major Mood Disorders by Daniel Murage; Vladislav Drobinin; Anna Nazarova; Emily Howes-Vallis; Carl Helmick; Matthias Schmidt; Aaron Newman; Christopher Bowen; Rudolf Uher is a Neuroscience article available to read on EtoBox.

What is 4. Brain Default Mode Network Connectivity and Familial Risk of Major Mood Disorders about?

Background: Understanding the potential causal relation- ships and the biological bases underlying the well-known associations between chronic pain and substance use disorders (SUD) could help to develop personalized early intervention tools for patients in need.Methods: Genome-wide association statistics were derived from the UK Biobank for multisite chronic pain (MCP) and from Million Veteran Program and the Psychiatric Genomics Consortium meta-analyses for alcohol use disorder (AUD), cannabis use disorder (CUD), opioid use disorder (OUD), and problematic tobacco use (PTU). Heritability and genetic correlation analyses were conducted using Linkage Disequilibrium Score Regression approach. Bidirectional Mendelian Randomization analyses were conducted using the TwoSam-pleMR package. Finally, we performed a genome-wide pleiotropy analysis using the PolarMorphism package. Results : MCP was positively genetically correlated with AUD (rg1⁄40.26, p1⁄47.5510-18), CUD (rg1⁄40.37, p1⁄48.2110-37), OUD (rg1⁄40.20, p1⁄41.5010-3), and PTU (rg1⁄40.29, p1⁄48.5310-12). We identified a bi-directional genomic causal relationship, wherein MCP had a much larger effect on AUD (betapain-exposure1⁄4

Who reads 4. Brain Default Mode Network Connectivity and Familial Risk of Major Mood Disorders?

Author

Daniel Murage; Vladislav Drobinin; Anna Nazarova; Emily Howes-Vallis; Carl Helmick; Matthias Schmidt; Aaron Newman; Christopher Bowen; Rudolf Uher

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)