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Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model by Sharavana, Gurunathan; Joseph, G. S.; Baskaran, Vallikannan is a Medicine article available to read on EtoBox.

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European Journal of Nutrition, doi:10.1007/s00394-016-1283-0 Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model 1 Abstract 1 Purpose 1 Methods 1 Results 1 Conclusion 1 Introduction 1 Materials and methods 2 Chemicals and reagents 2 Lutein isolation and mixed micelles preparation 2 Experimental design 3 Diabetes induction 3 Weight gain, feed intake and urine glucose 3 Oral glucose tolerance test 3 Tissue processing 3 Histopathology 3 MDA, GSH:GSSG and ROS analysis 3 Polyol pathway enzyme assays 4 Antioxidant enzymes 4 Lutein profiling 4 Statistical analysis 4 Results 4 Fasting blood glucose, feeding efficiency, organ weight and urine output 4 Aldose reductase and sorbitol dehydrogenase activity 6 MDA level and antioxidant status 6 Histopathogical characteristics of heart and kidney 6 Discussion 6 Conclusion 9 Acknowledgments 10 References 10 Diabetes;,Lutein;,Nephropathy;,Polyol,pathway;,Oxidative,stress Diabetes; Lutein; Nephropathy; Polyol pathway; Oxidative stress Lutein attenuates oxidative stress markers and聽ameliorates glucose homeostasis through聽polyol pathway i

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Author

Sharavana, Gurunathan; Joseph, G. S.; Baskaran, Vallikannan

Publisher

Springer; Springer-Verlag; Dr. Dietrich Steinkopff Verlag; Springer Science and Business Media LLC (ISSN 1436-6207)

Published

2016

Field

Medicine (Health Sciences)