Skip to content

Opening book details…

Can I read Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD) on EtoBox?

Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD) by Wang, Xiaobin (author);Tan, Yanlin (author);Liu, Fusheng (author);Wang, Jingyu (author);Liu, Fubin (author);Zhang, Qianshi (author);Li, Jing (author) is a Medicine article available to read on EtoBox.

What is Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD) about?

## Background Senescence and apoptosis of the nucleus pulposus cells (NPCs) are essential components of the intervertebral disc degeneration (IDD) process. Senescence and anti-apoptosis treatments could be effective ways to delay or even stop disc degeneration. IDD has been treated with __Eucommia ulmoides__ Oliver (Du Zhong, DZ) and its active ingredients. However, the roles and mechanisms of DZ in NPC apoptosis and senescence remain unclear. ## Methods Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to select the main active ingredients of DZ with the threshold of oral bioavailability (OB) ≥ 30% and drug-likeness (DL) ≥ 0.2. GSE34095 contained expression profile of degenerative intervertebral disc tissues and non-degenerative intervertebral disc tissues were downloaded for different expression genes analysis. The disease targets genes of IDD were retrieved from GeneCards. The online tool Metascape was used for functional enrichment annotation analysis. The specific effects of the ingredient on IL-1β treated NPC cell proliferation, cell senescence, reactive oxygen species (ROS) accumulation and cell apoptosis were determined by CCK-8, SA-β-gal stain

Who reads Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD)?

It is typically read by researchers, students, and practitioners in Medicine.

Author
Wang, Xiaobin (author);Tan, Yanlin (author);Liu, Fusheng (author);Wang, Jingyu (author);Liu, Fubin (author);Zhang, Qianshi (author);Li, Jing (author)
Publisher
Elsevier BV
Published
2023
Language
EN
Field
Medicine (Health Sciences)

More by Wang, Xiaobin (author);Tan, Yanlin (author);Liu, Fusheng (author);Wang, Jingyu (author);Liu, Fubin (author);Zhang, Qianshi (author);Li, Jing (author)

Browse all works by Wang, Xiaobin (author);Tan, Yanlin (author);Liu, Fusheng (author);Wang, Jingyu (author);Liu, Fubin (author);Zhang, Qianshi (author);Li, Jing (author)