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A Cost-minimization Analysis of Diuretic-based Antihypertensive Therapy Reducing Cardiovascular Events in Older Adults with Isolated Systolic Hypertension by G John Chen; Luigi Ferrucci; William P Moran; Marco Pahor is a Economics, Econometrics and Finance article available to read on EtoBox.

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## Background Hypertension is among the most common chronic condition in middle-aged and older adults. Approximately 50 million Americans are currently diagnosed with this condition, and more than $18.7 billion is spent on hypertension management, including $3.8 billion for medications. There are numerous pharmacological agents that can be chosen to treat hypertension by physicians in clinical practices. The purpose of this study was to assess the cost of alternative antihypertensive treatments in older adults with isolated systolic hypertension (ISH). ## Method Using the Systolic Hypertension in the Elderly Program (SHEP) and other data, a cost-minimization analysis was performed. The cost was presented as the cost of number-needed-to treat (NNT) of patients for 5 years to prevent one adverse event associated with cardiovascular disease (CVD). ## Result It was found that the cost of 5 year NNT to prevent one adverse CVD event ranged widely from $6,843 to $37,408 in older patients with ISH. The incremental cost of the 5 year NNT was lower to treat older patients in the very high CVD risk group relative to patients in the lower CVD risk group, ranging from $456 to $15,511. Compared

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Author

G John Chen; Luigi Ferrucci; William P Moran; Marco Pahor

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, c2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1478-7547)

Published

2005

Field

Economics, Econometrics and Finance (Social Sciences)