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Prevalence of Types 16 and 33 Is Increased in High-risk Human Papillomavirus Positive Women with Cervical Intraepithelial Neoplasia Grade 2 or Worse by Nicole W.J. Bulkmans; Maaike C.G. Bleeker; Johannes Berkhof; Feja J. Voorhorst; Peter J.F. Snijders; Chris J.L.M. Meijer is a Medicine article available to read on EtoBox.

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## Abstract High‐risk human papillomavirus (hrHPV) types are causally related to cervical cancer and its high‐grade precursor lesions. The risk posed by the different hrHPV types for the development of cervical intraepithelial neoplasia grade 2 or worse (≥CIN2) needs to be established. Here, we present the hrHPV type‐distribution in relation to cytology and histology for women participating in a cervical screening program. From 44,102 women who participated in a population‐based cervical screening program in the Netherlands, 2,154 hrHPV GP5+/6+ PCR positive women were recruited to determine the distribution of 14 hrHPV types by reverse line blotting of GP5+/6+ PCR products. For each HPV type, associations with cytology and histologically confirmed ≥CIN2 were measured by odds ratios. HPV types 16 and 33 were more prevalent in women, amongst those containing a single hrHPV type, with moderate dyskaryosis or worse (>BMD) than in women with normal cytology, but only in case of underlying ≥CIN2 (OR 4.10, 95%CI 2.98–5.64 and OR 2.68, 95%CI 1.39–5.15, respectively). Similar results were obtained for women with double infections (OR 3.29, 95% CI 1.61–6.75 and OR 4.37, 95% CI 1.17–16.34). C

Who reads Prevalence of Types 16 and 33 Is Increased in High-risk Human Papillomavirus Positive Women with Cervical Intraepithelial Neoplasia Grade 2 or Worse?

Author

Nicole W.J. Bulkmans; Maaike C.G. Bleeker; Johannes Berkhof; Feja J. Voorhorst; Peter J.F. Snijders; Chris J.L.M. Meijer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)