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Can I read ZnCl~2~ catalyzed new coumarinyl-chalcones as cytotoxic agents on EtoBox?
ZnCl~2~ catalyzed new coumarinyl-chalcones as cytotoxic agents by Sathish Kumar, Konidala; Kotra, Vijay; Phani Kumar Kola, ; Praveena Devi, CH.B.; Anusha, Nutakki; Hari Babu, Bollikolla; Adil, Syed Farooq; Shaik, Mohammed Rafi; Khan, Mujeeb; Al-Warthan, Abdulrahman; Alduhaish, Osamah; Mujahid Alam, M. is a Agricultural and Biological Sciences article available to read on EtoBox.
What is ZnCl~2~ catalyzed new coumarinyl-chalcones as cytotoxic agents about?
A new series of coumarin-yl-chalcone derivatives (**3a-m**) had been designed and synthesized through different reactions such as aromatic addition, cyclization and Claisen-Schmidt reactions in good yields (54–78%). 5-acetyl-4-(2-hydroxyphenyl) -6-methyl-3, 4-dihydropyrimidin-2(1H) -one **(1)** has been synthesized by multi-component one pot reaction of salicylaldehyde, methyl acetoacetate and urea, which was further reacted with malonic acid employing ZnCl~2~ catalyst to yield 5-acetyl-4-(4-hydroxy-2-oxo-2__H__-chromen-8-yl) -6-methyl-3, 4-dihydropyrimidin-2(1__H__) -one **(2).** The title compounds (**3a-m)** were synthesised by reacting 5-acetyl-4-(4-hydroxy-2-oxo-2__H__-chromen-8-yl) -6-methyl-3, 4-dihydropyrimidin-2(1__H__)-one (**2**) with different aromatic aldehydes in the presence of potassium hydroxide. __In silico__ studies, a preliminary screening method for predicting the anti-cancer activity was performed for the synthesized compounds (**3a-m)** against Src, Alb tyrosine kinase and homology model protein (PDB ID: 4csv). The derivatives **3h** and **3m** showed moderate binding energies. The __in vitro__ cytotoxic activity was evaluated for the compounds **3h** and **3
Who reads ZnCl~2~ catalyzed new coumarinyl-chalcones as cytotoxic agents?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Sathish Kumar, Konidala; Kotra, Vijay; Phani Kumar Kola, ; Praveena Devi, CH.B.; Anusha, Nutakki; Hari Babu, Bollikolla; Adil, Syed Farooq; Shaik, Mohammed Rafi; Khan, Mujeeb; Al-Warthan, Abdulrahman; Alduhaish, Osamah; Mujahid Alam, M.
- Publisher
- Elsevier ; King Saud University; Elsevier BV (ISSN 1319-562X)
- Published
- 2021
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)