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Effects of ritanserin, a selective and specific S2-serotonergic antagonist, on portal pressure and splanchnic hemodynamics in rats with long-term bile duct ligation by Mercedes Fernández; Pilar Pizcueta; Juan Carlos García-Pagán; Faust Feu; Isabel Cirera; Dr. Jaime Bosch; Joan Rodés is a Medicine article available to read on EtoBox.

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This study investigated the short-term effects of ritanserin, a selective and specific S2-serotonergic antagonist, in an experimental model of cirrhosis and intrahepatic portal hypertension caused by long-term bile duct ligation and division and in normal control rats. The rats subjected to bile duct ligation were randomized under blind conditions into two groups to receive ritanserin (0.7 mgikg body wt, intravenously; n = 10) or the same volume of placebo (isotonic saline solution; n = 10). We performed hemodynamic studies with radiolabeled microspheres 60 min after drug administration. Two groups of normal rats (n = 6) were studied after they received ritanserin or placebo. Ritanserin administration to rats subjected to bile duct ligation significantly reduced portal pressure (from 16.2 f 1.3 mm Hg to 12.3 f 0.7 mm Hg; mean decrease, 22% f 5%; p < 0.05). This reduction was associated with lower portal venous resistance (4.3 k 0.5 mm Hg \* min -100 gm/ml in the placebo group vs. 3.1 f 0.3 mm Hg mine 100 gm/ml in rats given ritanserin; mean decrease, 28%; p = 0.069), but we saw no changes in portal vein inflow (3.9 2 0.5 ml/min -100 g m vs. 4.4 -+ 0.4 ml/min. 100 gm), mean arterial

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Author

Mercedes Fernández; Pilar Pizcueta; Juan Carlos García-Pagán; Faust Feu; Isabel Cirera; Dr. Jaime Bosch; Joan Rodés

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1993

Language

EN

Field

Medicine (Health Sciences)