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The Clinical Status of Cadaveric Renal Transplant Patients Treated for 10 Year with Cyclosporine Therapy by Claudio Ponticelli; Adriana Aroldi; Attilio Elli; Giuseppe Montagnino; Antonio Vegeto; Antonio Tarantino is a Medicine article available to read on EtoBox.

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In this paper we assessed the clinical status of 150 cadaveric renal transplant patients who received cyclosporine without interruption for 10 yr. The mean creatinine clearance was 59.2±15.71 at 1 yr and 55.6±24.91 mL/min at 10 yr (p=0.039). Patients were subdivided into four quartiles according to the mean creatinine clearance at 1 yr. The 14 patients with the lowest quartile showed a significant decrease of creatinine clearance from the 1st to 10th year (from 31.5±5.83 to 24.8±14.00 mL/min; p=0.038) while no difference between the mean creatinine clearance at 1 and at 10 yr was found in the other three quartiles. At 10 yr, 84.6% patients needed antihypertensive therapy, a rate similar to that seen at 1 yr (81.4%). The mean plasma cholesterol (253±57.8 mg/dL) and triglyceride (197±113.1 mg/dL) at 10 yr were similar to those found at 1 yr (243±48.2 and 201±143.0 mg/dL, respectively). Most patients have a high degree of rehabilitation 10 yr after uninterrupted cyclosporine therapy and all patients but 3 were able to work.

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Author

Claudio Ponticelli; Adriana Aroldi; Attilio Elli; Giuseppe Montagnino; Antonio Vegeto; Antonio Tarantino

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0063)

Published

1999

Language

EN

Field

Medicine (Health Sciences)