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Protective roles of melatonin against the amyloid-dependent development of Alzheimer’s disease: A critical review by Bruno Vincent is a Medicine article available to read on EtoBox.

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Since its discovery almost 60 years ago by Lerner and colleagues, melatonin (N-acetyl-5-metoxytryptamine), a hormone mainly produced in the pineal gland, has been the subject of numerous investigations aimed at establishing its physiological functions. The subsequent seminal observation that melatonin levels decrease during normal aging, combined with the facts that AD patients show melatonin deficits when compared to age-matched controls and that the extent of melatonin loss in the cerebrospinal fluid parallels the progression of the disease, was the starting point of a series of studies, conducted during the past 20 years, aimed at determining whether this non-peptide hormone could reasonably be considered as a possible promising anti-AD compound and at establishing through which mechanisms it can control the time course of the disease. In this context, particular attention has been paid to the amyloid peptide (Aβ), which, according to the now well accepted "amyloid cascade" hypothesis, is a key element of the pathology. Indeed, works performed in vitro and in vivo, thanks to the development of reliable mouse models of the pathology, consistently proved melatonin as an efficient

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Author

Bruno Vincent

Published

2018

Language

EN

Field

Medicine (Life Sciences)