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Interferon production by Theileria annulata ‐transformed cell lines is restricted to the beta family by HEINZ SAGER; CHRISTELLE BRUNSCHWILER; THOMAS W. JUNGI is a Medicine article available to read on EtoBox.

What is Interferon production by Theileria annulata ‐transformed cell lines is restricted to the beta family about?

Theileria __are tick‐transmitted protozoans causing often fatal diseases in ruminants__. Theileria __sporozoites immortalize and transform host cells of haematopoietic origin. Transformation is associated with profound functional alterations. For example, bovine cells infected by__ Theileria annulata __or__ T. parva__. constitutively produce interferon (IFN). In this study, the type and family of IFN produced by a panel of__ T. annulata__‐transformed cell lines and a__ T. parva__‐transformed cell line was investigated, using molecular probes specific for the members of the IFN‐α, IFN‐β, IFN‐γ and IFN‐ω family__. T. parva__‐transformed cells produced IFN‐γ exclusively, whereas__ T. annulata__‐infected cells expressed type I IFN only. Analysis of mRNA expression showed that this type I IFN was confined to IFN‐β, regardless of the cellular origin of the transformed cells. When cells were exposed to double‐stranded RNA (poly (I:C)) which induces IFN production in other systems, a 10–5,000fold increase in IFN activity was noted. The amounts of IFN‐β mRNA were inceased, but mRNA coding for IFN‐α, IFN‐ω or IFN‐γ was not detected. In contrast, primary macrophages, from which many of the te

Who reads Interferon production by Theileria annulata ‐transformed cell lines is restricted to the beta family?

Author

HEINZ SAGER; CHRISTELLE BRUNSCHWILER; THOMAS W. JUNGI

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; FASEB (ISSN 0141-9838)

Published

1998

Language

EN

Field

Medicine (Health Sciences)